Yukiko Nakano, DDS, PhD

Associate Professor
Department of Orofacial Sciences
Publications: 

Targeted deep sequencing analyses of long QT syndrome in a Japanese population.

PloS one

Nagata Y, Watanabe R, Eichhorn C, Ohno S, Aiba T, Ishikawa T, Nakano Y, Aizawa Y, Hayashi K, Murakoshi N, Nakajima T, Yagihara N, Mishima H, Sudo T, Higuchi C, Takahashi A, Sekine A, Makiyama T, Tanaka Y, Watanabe A, Tachibana M, Morita H, Yoshiura KI, Tsunoda T, Watanabe H, Kurabayashi M, Nogami A, Kihara Y, Horie M, Shimizu W, Makita N, Tanaka T

GJA1 gene polymorphism is a genetic predictor of recurrence after pulmonary vein isolation in patients with paroxysmal atrial fibrillation.

Heart rhythm

Okamura S, Ochi H, Onohara Y, Nakashima M, Akiyama R, Tokuyama T, Okubo Y, Ikeuchi Y, Miyauchi S, Miyamoto S, Oguri N, Uotani Y, Odake Y, Chayama K, Kihara Y, Nakano Y

Effects of Early Life Adversity on Tooth Enamel Formation.

Frontiers in dental medicine

Shaffer IC, Nakano Y, Pham A, Short A, Nanci A, Zhang Y, Shemirani R, Den Besten PK

WDR72 regulates vesicle trafficking in ameloblasts.

Scientific reports

Katsura K, Nakano Y, Zhang Y, Shemirani R, Li W, Den Besten P

Predominant Posterior Annular Dilatation Is Associated with Vena Contracta Morphology in Atrial Functional Tricuspid Regurgitation.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

Utsunomiya H, Yoshida J, Izumi K, Takemoto H, Ueda Y, Nakano Y, Shiota T

Minor allele of GJA1 gene polymorphism is associated with higher heart rate during atrial fibrillation.

Scientific reports

Okamura S, Onohara Y, Ochi H, Tokuyama T, Hironobe N, Okubo Y, Ikeuchi Y, Miyauchi S, Chayama K, Kihara Y, Nakano Y

Fluoride Alters Signaling Pathways Associated with the Initiation of Dentin Mineralization in Enamel Fluorosis Susceptible Mice.

Biological trace element research

Kao YH, Igarashi N, Abduweli Uyghurturk D, Li Z, Zhang Y, Ohshima H, MacDougall M, Takano Y, Den Besten P, Nakano Y

Successful catheter ablation of persistent atrial fibrillation is associated with improvement in functional tricuspid regurgitation and right heart reverse remodeling.

Heart and vessels

Itakura K, Hidaka T, Nakano Y, Utsunomiya H, Kinoshita M, Susawa H, Harada Y, Izumi K, Kihara Y

SATB1 establishes ameloblast cell polarity and regulates directional amelogenin secretion for enamel formation.

BMC biology

Zhang Y, Zheng L, Le M, Nakano Y, Chan B, Huang Y, Torbaty PM, Kohwi Y, Marcucio R, Habelitz S, Den Besten PK, Kohwi-Shigematsu T

Fluoride related changes in behavioral outcomes may relate to increased serotonin.

Physiology & behavior

Lu F, Zhang Y, Trivedi A, Jiang X, Chandra D, Zheng J, Nakano Y, Abduweli Uyghurturk D, Jalai R, Onur SG, Mentes A, DenBesten PK

Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites.

Glycobiology

Mito A, Nakano Y, Saitoh T, Gouraud SSS, Yamaguchi Y, Sato T, Sasaki N, Kojima-Aikawa K

Fluoride Alters Klk4 Expression in Maturation Ameloblasts through Androgen and Progesterone Receptor Signaling.

Frontiers in physiology

Le MH, Nakano Y, Abduweli Uyghurturk D, Zhu L, Den Besten PK

Syncope in patients with inherited arrhythmias.

Journal of arrhythmia

Nakano Y, Wataru S

Genotype-Phenotype Correlation of SCN5A Mutation for the Clinical and Electrocardiographic Characteristics of Probands With Brugada Syndrome: A Japanese Multicenter Registry.

Circulation

Yamagata K, Horie M, Aiba T, Ogawa S, Aizawa Y, Ohe T, Yamagishi M, Makita N, Sakurada H, Tanaka T, Shimizu A, Hagiwara N, Kishi R, Nakano Y, Takagi M, Makiyama T, Ohno S, Fukuda K, Watanabe H, Morita H, Hayashi K, Kusano K, Kamakura S, Yasuda S, Ogawa H, Miyamoto Y, Kapplinger JD, Ackerman MJ, Shimizu W

Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes.

Journal of the American Heart Association

Yagihara N, Watanabe H, Barnett P, Duboscq-Bidot L, Thomas AC, Yang P, Ohno S, Hasegawa K, Kuwano R, Chatel S, Redon R, Schott JJ, Probst V, Koopmann TT, Bezzina CR, Wilde AA, Nakano Y, Aiba T, Miyamoto Y, Kamakura S, Darbar D, Donahue BS, Shigemizu D, Tanaka T, Tsunoda T, Suda M, Sato A, Minamino T, Endo N, Shimizu W, Horie M, Roden DM, Makita N

A Critical Role of TRPM7 As an Ion Channel Protein in Mediating the Mineralization of the Craniofacial Hard Tissues.

Frontiers in physiology

Nakano Y, Le MH, Abduweli D, Ho SP, Ryazanova LV, Hu Z, Ryazanov AG, Den Besten PK, Zhang Y

Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the Repolarization Current.

Circulation. Arrhythmia and electrophysiology

Nakano Y, Ochi H, Onohara Y, Toshishige M, Tokuyama T, Matsumura H, Kawazoe H, Tomomori S, Sairaku A, Watanabe Y, Ikenaga H, Motoda C, Suenari K, Hayashida Y, Miki D, Oda N, Kishimoto S, Oda N, Yoshida Y, Tashiro S, Chayama K, Kihara Y

Amelogenin Exon4 Forms a Novel miRNA That Directs Ameloblast and Osteoblast Differentiation.

Journal of dental research

Le MH, Warotayanont R, Stahl J, Den Besten PK, Nakano Y

Genetics of long-QT syndrome.

Journal of human genetics

Nakano Y, Shimizu W

Exon4 amelogenin transcripts in enamel biomineralization.

Journal of dental research

Stahl J, Nakano Y, Horst J, Zhu L, Le M, Zhang Y, Liu H, Li W, Den Besten PK

Fluorosed mouse ameloblasts have increased SATB1 retention and Gαq activity.

PloS one

Zhang Y, Kim JY, Horst O, Nakano Y, Zhu L, Radlanski RJ, Ho S, Den Besten PK

WDR72 models of structure and function: a stage-specific regulator of enamel mineralization.

Matrix biology : journal of the International Society for Matrix Biology

Katsura KA, Horst JA, Chandra D, Le TQ, Nakano Y, Zhang Y, Horst OV, Zhu L, Le MH, DenBesten PK

Leucine rich amelogenin peptide alters ameloblast differentiation in vivo.

Matrix biology : journal of the International Society for Matrix Biology

Stahl J, Nakano Y, Kim SO, Gibson CW, Le T, DenBesten P

A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation.

PLoS genetics

Nakano Y, Chayama K, Ochi H, Toshishige M, Hayashida Y, Miki D, Hayes CN, Suzuki H, Tokuyama T, Oda N, Suenari K, Uchimura-Makita Y, Kajihara K, Sairaku A, Motoda C, Fujiwara M, Watanabe Y, Yoshida Y, Ohkubo K, Watanabe I, Nogami A, Hasegawa K, Watanabe H, Endo N, Aiba T, Shimizu W, Ohno S, Horie M, Arihiro K, Tashiro S, Makita N, Kihara Y

ZG16p, an animal homolog of β-prism fold plant lectins, interacts with heparan sulfate proteoglycans in pancreatic zymogen granules.

Glycobiology

Kumazawa-Inoue K, Mimura T, Hosokawa-Tamiya S, Nakano Y, Dohmae N, Kinoshita-Toyoda A, Toyoda H, Kojima-Aikawa K

Comparative temporospatial expression profiling of murine amelotin protein during amelogenesis.

Cells, tissues, organs

Somogyi-Ganss E, Nakayama Y, Iwasaki K, Nakano Y, Stolf D, McKee MD, Ganss B

Enzyme replacement therapy prevents dental defects in a model of hypophosphatasia.

Journal of dental research

McKee MD, Nakano Y, Masica DL, Gray JJ, Lemire I, Heft R, Whyte MP, Crine P, Millán JL

A spontaneous Type 1 electrocardiogram pattern in lead V2 is an independent predictor of ventricular fibrillation in Brugada syndrome.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

Nakano Y, Shimizu W, Ogi H, Suenari K, Oda N, Makita Y, Kajihara K, Hirai Y, Sairaku A, Tokuyama T, Tonouchi Y, Ueda S, Sueda T, Chayama K, Kihara Y

MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Addison WN, Nakano Y, Loisel T, Crine P, McKee MD

Disopyramide for transient high-degree atrioventricular block in a young patient with a history of syncope.

Journal of cardiology

Hirai Y, Yamamoto H, Nakano Y, Ogi H, Kajiwara S, Kohno N

Connexin43 knockdown accelerates wound healing but inhibits mesenchymal transition after corneal endothelial injury in vivo.

Investigative ophthalmology & visual science

Nakano Y, Oyamada M, Dai P, Nakagami T, Kinoshita S, Takamatsu T

ATP-mediated mineralization of MC3T3-E1 osteoblast cultures.

Bone

Nakano Y, Addison WN, Kaartinen MT

Expression of bone type 1 PTH receptor in rats with chronic renal failure.

Clinical and experimental nephrology

Kuwahara M, Inoshita S, Nakano Y, Terada Y, Takano Y, Sasaki S

Expression and localization of plasma transglutaminase factor XIIIA in bone.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Nakano Y, Al-Jallad HF, Mousa A, Kaartinen MT

Gene delivery of paraoxonase-1 inhibits neointimal hyperplasia after arterial balloon-injury in rabbits fed a high-fat diet.

Hypertension research : official journal of the Japanese Society of Hypertension

Miyoshi M, Nakano Y, Sakaguchi T, Ogi H, Oda N, Suenari K, Kiyotani K, Ozono R, Oshima T, Yoshida T, Chayama K

Non-SCN5A related Brugada syndromes: verification of normal splicing and trafficking of SCN5A without exonic mutations.

Annals of human genetics

Nakano Y, Tashiro S, Kinoshita E, Kinoshita-Kikuta E, Takenaka S, Miyoshi M, Ogi H, Sakoda E, Oda N, Suenari K, Tonouchi Y, Okimoto T, Hirai Y, Miura F, Yamaoka K, Koike T, Chayama K

Formation of acellular cementum-like layers, with and without extrinsic fiber insertion, along inert bone surfaces of aging c-Src gene knockout mice.

European journal of oral sciences

Baba O, Miyata A, Abe T, Shibata S, Nakano Y, Terashima T, Oda T, Kudo A, Takano Y

Successive, rapid recurrences of in-stent restenoses in a woman with angina pectoris.

Internal medicine (Tokyo, Japan)

Ni L, Teragawa H, Ueda K, Takemoto H, Hidaka T, Nishioka K, Soga J, Oda N, Nakano Y, Shingu T, Chayama K

Proteolysis on maturing enamel surface, as shown by gel-coating methods.

European journal of oral sciences

Takano Y, Nakano Y, Yamamoto-Shuda Y, Baba O, Terashima T

Transglutaminase activity regulates osteoblast differentiation and matrix mineralization in MC3T3-E1 osteoblast cultures.

Matrix biology : journal of the International Society for Matrix Biology

Al-Jallad HF, Nakano Y, Chen JL, McMillan E, Lefebvre C, Kaartinen MT

Eccentric localization of osteocytes expressing enzymatic activities, protein, and mRNA signals for type 5 tartrate-resistant acid phosphatase (TRAP).

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Nakano Y, Toyosawa S, Takano Y

Matrix metalloproteinase-9 contributes to human atrial remodeling during atrial fibrillation.

Journal of the American College of Cardiology

Nakano Y, Niida S, Dote K, Takenaka S, Hirao H, Miura F, Ishida M, Shingu T, Sueda T, Yoshizumi M, Chayama K

The induction of enamel and dentin complexes by subcutaneous implantation of reconstructed human and murine tooth germ elements.

Archives of histology and cytology

Isogawa N, Terashima T, Nakano Y, Kindaichi J, Takagi Y, Takano Y

Possible role of dentin matrix in region-specific deposition of cellular and acellular extrinsic fibre cementum.

Journal of electron microscopy

Takano Y, Sakai H, Watanabe E, Ideguchi-Ohma N, Jayawardena CK, Arai K, Asawa Y, Nakano Y, Shuda Y, Sakamoto Y, Terashima T

A frameshift mutation of beta subunit of epithelial sodium channel in a case of isolated Liddle syndrome.

Journal of hypertension

Nakano Y, Ishida T, Ozono R, Matsuura H, Yamamoto Y, Kambe M, Chayama K, Oshima T