Amelogenesis imperfecta is a condition resulting from hereditary factors that lead to the malformation of enamel, compromising the protective barrier of our teeth. This malformation primarily arises due to mutations in genes that encode enamel matrix proteins. Dr. Zhang, backed by the…
Previous research has shown that fluoride ingestion can increase inflammation markers in rodents. However, making direct comparisons between rodent and human studies has been problematic because of the much higher water fluoride concentrations required for rodents.
In a recent study, Yakano and coworkers explored the role of the amelogenin gene, which produces the amelogenin protein crucial for enamel formation. Our findings revealed that miR-exon4, a miRNA originating from exon4 of the amelogenin gene, targets the transcription factor nuclear factor I/A (NFI…
Hematopoietic cell transplantation (HCT) offers a potential cure for various pediatric diseases, but complications like blood stream infections (BSI) pose significant risks. There's emerging evidence linking the oral microbiome, specifically bacteria such as S. mitis, to the onset of BSI. In…
Kallikrein related peptidase 4 (KLK4) is thought to play important role in the final stage of dental enamel formation by allowing for enamel crystal growth. In humans having a mutated KLK4 gene and in mice lacking Klk4 expression, the enamel becomes hypomineralized or hypomatured with discoloration…
Enamel, formed by ameloblast cells, is the hardest substance in human body, and the first defensive line for healthy tooth. Unfortunately, nearly 40% the incisor teeth in babies and children have some sort of enamel defect. To replace enamel, or even entire teeth, we need strategies to regenerate…
Dr. Ann George visited COHR on April, 2016 from the University of Illinois and gave the lecture on the topic "DMP1: A busy protein that functions in mineralized matrix assembly". Dr. George is a Professor at the Division of Oral Biology, University of Illinois, and an Allan G.
Amelogenins are the most abundant proteins in the developing enamel matrix, and the gene coding amelogenin is known to be highly alternatively spliced. The researchers from COHR have found that a novel microRNA (miRNA) is derived from amelogenin exon4 through the alternative splicing of amelogenin…
West China School of Stomalology, Sichuan University, China invited Dr Thuan Le, DDS, PhD, UCSF Pediatric Dentistry Associate professor and residency program director, as a guest speaker to represent UCSF Pediatric Dentistry at the the 8th Annual Session of Chinese Society of Pediatric Dentistry in…
The UC Berkeley Center for Global Public Health and UCSF Center for Children’s Oral Health Research held the 2014 Global Children’s Oral Health and Nutrition Symposium: Addressing Public Health Challenges Through Transdisciplinary Approaches on Tuesday, April 22, 2014.
